Dihydrotestosterone Formation (5α-Reductase Activity) in Cultured Human Skin Fibroblasts
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چکیده
منابع مشابه
[Dihydrotestosterone formation (5 alpha-reductase activity) in cultured human skin fibroblasts].
Testosterone secreted from the testis is converted to dihydrotestosterone (DHT) in target tissues by 5 alpha-reductase and DHT exerts its action on the nucleus. Since skin is one of the target tissues of androgen we established a system for culturing human skin fibroblasts, and we investigated the conversion of testosterone to DHT in genital and nongenital skin fibroblasts obtained from males a...
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The conversion of [1,2-3H]testosterone to [‘Hldihydrotestosterone has been assessed in fibroblast monolayers grown from skin biopsies of foreskin, scrotum, and various nongenital skins from 31 control men who varied in age from newborn to 25 years and three 46,XY subjects with hereditary male pseudohermaphroditism. Under the standardized conditions utilized in this study, the rate of dihydrotes...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1984
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.60.11_1281